Ongoing Research

A national study (sponsored by NIH-NIA) in which deceased patients’ families are consenting to provide a priceless donation to science to study COVID-19 effect on the brain.

This is an exciting and upcoming study designed to understand the link between delirium and dementia after critical illness.

A study of the effects of brain training and physical exercise on recovery after major surgery.

The Early Cognitive Intervention in Delirium (ECID) study is a randomized control trial designed to determine if early (<24 hours) cognitive training and rehabilitation improve 4-month global cognition in older delirious patients with and without Alzheimer’s disease and related dementias.

This Department of Defense (DoD) funded randomized clinical trial is to determine about if plasma transfusion can improve outcomes after traumatic brain injury.

NIH-funded observational study examining EEG signatures of ICU delirium and post-ICU cognitive impairment

An ongoing comprehensive long-term cognitive impairment study after traumatic injury and critical illness.

Industry-funded multicenter randomized controlled trial of inhaled isoflurane compared to intravenous propofol for sedation in the ICU

A national study of the effect of COVID-related isolation policies on patients, families, and healthcare providers in the ICU

A multicenter study of the role of a new drug for ICU delirium in COVID-19 patients

A randomized controlled trial to determine the best sedative medication to reduce delirium and improve functional and behavioral recovery in pediatric patients.

An ongoing observational study of the association between activity and physical and cognitive function in ICU survivors.

Pilot study, funded by the Brain and Behavior Research Foundation, examining feasibility of delivering remote neurofeedback training (Myndlift) to ICU survivors for improved psychological outcomes

A Department of Defense (DoD) randomized clinical trial of Neuromuscular electrical stimulation of abdominal muscles to assist ventilator weaning in critically ill patients

NIH/VA-Merit funded Randomized Controlled Trial on computerized cognitive rehabilitation after critical illness

NIH funded Randomized Controlled Trial of an Immunomodulator (Baricitinib) for Patients with Long COVID

The Randomized trial of Sedative choice for Intubation (RSI) trial is a randomized trial comparing ketamine versus etomidate’s effect on 1-month mortality and 12-month post-traumatic stress disorder symptoms in critically ill adults who are receiving a breathing tube in the emergency department or intensive care unit.

This is an industry-funded (CSL Behring) prospective, international, multicenter, randomized clinical trial to investigate the efficacy and safety of a 4-factor prothrombin complex concentrate ([Kcentra® / Beriplex®]) in subjects who have traumatic injury, with confirmed or suspected acute major ble