Discovery Timeline
Selected Historical Landmarks in Maturation of the Field of Delirium, Acute Brain Dysfunction in Critical Illness, Acquired-Dementia, Post-Intensive Care Syndrome (PICS) and the ABCDEF Bundle.
- Genesis of ABCDEFsYearLandmark
- 1952DSM I
- 1968DSM II
- 1980DSM III
- 2000DSM IV
- PICSHerridge et al, 1-year
 Functional Outcomes after ARDS
- AGelinas
 CPOT
- CPandharipande
 MENDS
- ESchweikert
 Early Mobility
- CStrøm
 No Sedation ProtocolABCDE
- PICSHerridge et al, 5-year
 Functional Outcomes after ARDS
- PICSCoining of term PICS for the Post-Intensive Care Syndrome
 Needham
 Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference.
- PICS1-year Cognitive Outcomes after ICU Care, establishing that neurological injury post-ICU illness is a hallmark injury in PICS, driven by delirium duration and qualifying as acquired dementiaPandharipande
 BRAIN-ICU StudyHan JH
 bCAM
- ABCDEF2017
- ABCDEF
- DAndersen-Ranberg
 Haloperidol for the Treatment of Delirium in ICU Patients


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